Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 6 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
We conducted a double-blind, placebo-controlled trial to see how nano-curcumin, a supplement derived from turmeric, affects heart health in overweight or obese patients with a condition known as coronary slow flow phenomenon (CSFP). Our study involved 42 participants who received either 80 mg of nano-curcumin or a placebo daily for 12 weeks.
To measure how angina—a type of chest pain—improved, we used the Seattle angina questionnaire among other cardiovascular risk factors, including endocan, adropin, homocysteine levels, and various lipid profiles.
At the end of the study, we observed that those taking nano-curcumin reported significant improvements in their angina status and some cardiovascular factors, compared to their baseline measures. While some improvements were also seen in traditional and novel risk factors, more research will be needed to understand these changes in depth and whether they offer any real-world benefits for heart health.
To measure how angina—a type of chest pain—improved, we used the Seattle angina questionnaire among other cardiovascular risk factors, including endocan, adropin, homocysteine levels, and various lipid profiles.
At the end of the study, we observed that those taking nano-curcumin reported significant improvements in their angina status and some cardiovascular factors, compared to their baseline measures. While some improvements were also seen in traditional and novel risk factors, more research will be needed to understand these changes in depth and whether they offer any real-world benefits for heart health.
Read More
8
We examined the potential effects of curcumin, a natural compound derived from turmeric, on heart disease. This vibrant yellow spice is touted for its numerous health benefits, particularly its ability to combat cardiovascular diseases, which are a leading cause of death globally.
Studies show that curcumin is protective against various heart issues. It can help shield heart cells from damage caused by ischemia and low oxygen levels. Moreover, it plays a role in reducing heart enlargement and fibrosis, enhancing how the heart remodels itself after injury, and protecting against drug-induced heart damage. Curcumin also shows promise in improving conditions like diabetic cardiomyopathy, reducing arterial blockages, and slowing the proliferation of certain harmful cells in the blood vessels.
While clinical studies affirm curcumin's protective effects on blood vessels and overall safety, it's essential to note that high doses may lead to some adverse effects, including potential liver damage and issues with heart development in embryos. Overall, this intriguing compound offers valuable insights and mechanisms that could guide future heart disease treatments.
Studies show that curcumin is protective against various heart issues. It can help shield heart cells from damage caused by ischemia and low oxygen levels. Moreover, it plays a role in reducing heart enlargement and fibrosis, enhancing how the heart remodels itself after injury, and protecting against drug-induced heart damage. Curcumin also shows promise in improving conditions like diabetic cardiomyopathy, reducing arterial blockages, and slowing the proliferation of certain harmful cells in the blood vessels.
While clinical studies affirm curcumin's protective effects on blood vessels and overall safety, it's essential to note that high doses may lead to some adverse effects, including potential liver damage and issues with heart development in embryos. Overall, this intriguing compound offers valuable insights and mechanisms that could guide future heart disease treatments.
Read More
9
We aimed to explore how curcumin, a compound found in turmeric, can help reduce heart damage caused by ischemia-reperfusion injury (MIRI). This type of injury occurs when blood supply returns to the heart after a period of being blocked, and it can lead to complications such as cell death and heart dysfunction.
Through our study involving Sprague-Dawley rats and H9c2 heart cells, we observed that curcumin pretreatment significantly improved heart health. It reduced damage to the heart muscle, increased cell survival, and minimized instances of ferroptosis—a form of cell death that contributes to heart injuries.
We found that when MIRI occurred, certain proteins in heart cells that help regulate cell survival were adversely affected. These proteins, including Sirt1 and FoxO3a, normally help protect cells from stress but were inhibited during MIRI. Remarkably, curcumin activated these protective pathways again, promoting survival and reducing harmful processes like ferroptosis and apoptosis.
Our findings highlight curcumin's potential as a therapeutic agent against myocardial injury, as it helps maintain healthy heart function by influencing specific molecular pathways. We also addressed that blocking these pathways negated the benefits of curcumin, showcasing the importance of the Sirt1/AKT/FoxO3a signaling in its protective effect against heart disease.
Through our study involving Sprague-Dawley rats and H9c2 heart cells, we observed that curcumin pretreatment significantly improved heart health. It reduced damage to the heart muscle, increased cell survival, and minimized instances of ferroptosis—a form of cell death that contributes to heart injuries.
We found that when MIRI occurred, certain proteins in heart cells that help regulate cell survival were adversely affected. These proteins, including Sirt1 and FoxO3a, normally help protect cells from stress but were inhibited during MIRI. Remarkably, curcumin activated these protective pathways again, promoting survival and reducing harmful processes like ferroptosis and apoptosis.
Our findings highlight curcumin's potential as a therapeutic agent against myocardial injury, as it helps maintain healthy heart function by influencing specific molecular pathways. We also addressed that blocking these pathways negated the benefits of curcumin, showcasing the importance of the Sirt1/AKT/FoxO3a signaling in its protective effect against heart disease.
Read More
Most Useful Reviews
9
Eliminated pain relief
14 people found this helpful
This is a fantastic product. I use it for its anti-inflammatory properties, which have allowed me to nearly stop using Ibuprofen. My cardiologist considers me his most boring patient after having two heart stents for almost six years. I also take nattokinase and serrapeptase to maintain excellent cardiovascular health.
Read More
9
Reduces joint pain
1 people found this helpful
After experiencing painful shoulders and toe joints, I found this product greatly eased my inflammation and pain, positively impacting my heart health.
Read More
7.5
Effective inflammation management
6 people found this helpful
Curcumin is an excellent anti-inflammatory and antioxidant. It halts osteoarthritis progression, reduces inflammation, and protects the liver. Curcumin is vital in my medicine cabinet for managing inflammation and has contributed positively to my heart health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
We aimed to explore how curcumin, a compound found in turmeric, can help reduce heart damage caused by ischemia-reperfusion injury (MIRI). This type of injury occurs when blood supply returns to the heart after a period of being blocked, and it can lead to complications such as cell death and heart dysfunction.
Through our study involving Sprague-Dawley rats and H9c2 heart cells, we observed that curcumin pretreatment significantly improved heart health. It reduced damage to the heart muscle, increased cell survival, and minimized instances of ferroptosis—a form of cell death that contributes to heart injuries.
We found that when MIRI occurred, certain proteins in heart cells that help regulate cell survival were adversely affected. These proteins, including Sirt1 and FoxO3a, normally help protect cells from stress but were inhibited during MIRI. Remarkably, curcumin activated these protective pathways again, promoting survival and reducing harmful processes like ferroptosis and apoptosis.
Our findings highlight curcumin's potential as a therapeutic agent against myocardial injury, as it helps maintain healthy heart function by influencing specific molecular pathways. We also addressed that blocking these pathways negated the benefits of curcumin, showcasing the importance of the Sirt1/AKT/FoxO3a signaling in its protective effect against heart disease.
Through our study involving Sprague-Dawley rats and H9c2 heart cells, we observed that curcumin pretreatment significantly improved heart health. It reduced damage to the heart muscle, increased cell survival, and minimized instances of ferroptosis—a form of cell death that contributes to heart injuries.
We found that when MIRI occurred, certain proteins in heart cells that help regulate cell survival were adversely affected. These proteins, including Sirt1 and FoxO3a, normally help protect cells from stress but were inhibited during MIRI. Remarkably, curcumin activated these protective pathways again, promoting survival and reducing harmful processes like ferroptosis and apoptosis.
Our findings highlight curcumin's potential as a therapeutic agent against myocardial injury, as it helps maintain healthy heart function by influencing specific molecular pathways. We also addressed that blocking these pathways negated the benefits of curcumin, showcasing the importance of the Sirt1/AKT/FoxO3a signaling in its protective effect against heart disease.
Read More
9
We explored how turmeric, specifically its active component curcumin, can protect the heart in cases of ischemia/reperfusion injury. This phenomenon often occurs during acute myocardial infarction when the heart muscle suffers due to restricted blood flow followed by restoration. Our focus was to understand whether curcumin could mitigate the damage caused by this process.
Through our research, we observed that curcumin appeared to significantly improve cell viability and reduce factors indicating cell damage. We noted that, in settings of anoxia/reoxygenation injury, curcumin treatment successfully lowered oxidative stress markers and enhanced antioxidant defenses in the heart cells. This included positive impacts on important proteins involved in protecting cells from ferroptosis (a type of cell death) and apoptosis (programmed cell death).
Furthermore, curcumin also improved mitochondrial function, which is crucial for heart cell energy production and overall health. We found that curcumin pretreatment inhibited excessive autophagy activation, which otherwise could contribute to cell damage under stress. These protective effects were correlated with increased expression of HES1, a protein linked to cell survival.
However, we noticed that the protective effects of curcumin were diminished when we tested alongside ferroptosis inducers or autophagy activators. This indicates that while curcumin has robust protective capabilities against heart injury, its effectiveness can be influenced by other cellular processes in play.
In conclusion, curcumin shows promising potential as a natural treatment option to reduce heart damage from ischemia/reperfusion injury, primarily through its antioxidant properties and influence on critical survival pathways.
Through our research, we observed that curcumin appeared to significantly improve cell viability and reduce factors indicating cell damage. We noted that, in settings of anoxia/reoxygenation injury, curcumin treatment successfully lowered oxidative stress markers and enhanced antioxidant defenses in the heart cells. This included positive impacts on important proteins involved in protecting cells from ferroptosis (a type of cell death) and apoptosis (programmed cell death).
Furthermore, curcumin also improved mitochondrial function, which is crucial for heart cell energy production and overall health. We found that curcumin pretreatment inhibited excessive autophagy activation, which otherwise could contribute to cell damage under stress. These protective effects were correlated with increased expression of HES1, a protein linked to cell survival.
However, we noticed that the protective effects of curcumin were diminished when we tested alongside ferroptosis inducers or autophagy activators. This indicates that while curcumin has robust protective capabilities against heart injury, its effectiveness can be influenced by other cellular processes in play.
In conclusion, curcumin shows promising potential as a natural treatment option to reduce heart damage from ischemia/reperfusion injury, primarily through its antioxidant properties and influence on critical survival pathways.
Read More
9
We explored how curcumin, a compound found in turmeric, might help reduce the risk of atrial fibrillation (AF) among older adults. In our research, we used aged mice to study the effects of curcumin on the heart, particularly focusing on atrial conditions that are common with aging.
By treating these mice with curcumin, we noticed a decrease in factors that contribute to AF, such as aging-related atrial fibrosis. Through our experiments, we identified specific small RNA molecules, known as transfer RNA-derived small RNAs (tsRNAs), that became significantly altered with curcumin treatment, hinting at a potential mechanism through which curcumin exerts its protective effects.
Interestingly, we observed that specific tsRNAs associated with oxidative stress and inflammation were regulated, indicating that curcumin not only impacts aging-related changes but could also play a role in managing heart health as we age. Our findings shed light on a promising new avenue for using curcumin as an intervention for atrial fibrillation linked to aging.
By treating these mice with curcumin, we noticed a decrease in factors that contribute to AF, such as aging-related atrial fibrosis. Through our experiments, we identified specific small RNA molecules, known as transfer RNA-derived small RNAs (tsRNAs), that became significantly altered with curcumin treatment, hinting at a potential mechanism through which curcumin exerts its protective effects.
Interestingly, we observed that specific tsRNAs associated with oxidative stress and inflammation were regulated, indicating that curcumin not only impacts aging-related changes but could also play a role in managing heart health as we age. Our findings shed light on a promising new avenue for using curcumin as an intervention for atrial fibrillation linked to aging.
Read More
8
Curcumin shows promise for metabolic health
We examined how curcumin, a key ingredient in turmeric, impacts cardiometabolic health in women with polycystic ovary syndrome (PCOS), a condition often linked to heart disease risks. In our systematic review, we analyzed data from eight randomized clinical trials to understand if curcumin could be beneficial for controlling various metabolic factors.
Our findings suggest that curcumin supplementation can lead to significant reductions in fasting blood sugar levels, insulin resistance, and total cholesterol among women suffering from PCOS. Specifically, we noticed substantial improvements in markers like the homeostasis model assessment of insulin resistance and the quantitative insulin sensitivity check index, which are crucial for heart health.
However, it’s important to highlight that while curcumin shows promise in addressing these metabolic issues, it did not significantly impact body mass index or other hormonal levels related to heart disease risk. Thus, while curcumin supplementation might improve certain metabolic factors, its direct effects on heart disease require further exploration.
Our findings suggest that curcumin supplementation can lead to significant reductions in fasting blood sugar levels, insulin resistance, and total cholesterol among women suffering from PCOS. Specifically, we noticed substantial improvements in markers like the homeostasis model assessment of insulin resistance and the quantitative insulin sensitivity check index, which are crucial for heart health.
However, it’s important to highlight that while curcumin shows promise in addressing these metabolic issues, it did not significantly impact body mass index or other hormonal levels related to heart disease risk. Thus, while curcumin supplementation might improve certain metabolic factors, its direct effects on heart disease require further exploration.
Read More
8
Curcumin shows promise for heart health
In our exploration of heart disease treatment, we focused on cardiac fibrosis, a condition that can lead to serious heart issues such as failure. We utilized a well-structured approach, employing both in-vitro and in-vivo techniques to assess the effectiveness of dendrosomal nano-curcumin (DNC), a powerful form of curcumin derived from turmeric.
To start, we induced cardiac fibrosis in primary cardiac fibroblasts using isoproterenol (ISO) and subsequently treated them with DNC. Through rigorous testing, we found that DNC significantly lessened the fibrotic effects of ISO, indicating its potential as a therapeutic agent.
Following this, we investigated the impact of ISO in a live mouse model and noticed that it triggered fibrosis not only in the heart but also in the lungs. The application of DNC before, during, or after ISO treatment led to a marked reduction in fibrosis symptoms. This suggests that DNC could serve as both a preventive agent and a treatment alternative for those facing heart challenges related to fibrosis.
Our findings also revealed interesting genetic insights indicating the COMP gene as a potential new marker associated with cardiac fibrosis. Overall, this research highlights the promising role of DNC in combating heart disease and offers a hopeful outlook for future treatments.
To start, we induced cardiac fibrosis in primary cardiac fibroblasts using isoproterenol (ISO) and subsequently treated them with DNC. Through rigorous testing, we found that DNC significantly lessened the fibrotic effects of ISO, indicating its potential as a therapeutic agent.
Following this, we investigated the impact of ISO in a live mouse model and noticed that it triggered fibrosis not only in the heart but also in the lungs. The application of DNC before, during, or after ISO treatment led to a marked reduction in fibrosis symptoms. This suggests that DNC could serve as both a preventive agent and a treatment alternative for those facing heart challenges related to fibrosis.
Our findings also revealed interesting genetic insights indicating the COMP gene as a potential new marker associated with cardiac fibrosis. Overall, this research highlights the promising role of DNC in combating heart disease and offers a hopeful outlook for future treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eliminated pain relief
14 people found this helpful
This is a fantastic product. I use it for its anti-inflammatory properties, which have allowed me to nearly stop using Ibuprofen. My cardiologist considers me his most boring patient after having two heart stents for almost six years. I also take nattokinase and serrapeptase to maintain excellent cardiovascular health.
Read More
9
Reduces joint pain
1 people found this helpful
After experiencing painful shoulders and toe joints, I found this product greatly eased my inflammation and pain, positively impacting my heart health.
Read More
7.5
Effective inflammation management
6 people found this helpful
Curcumin is an excellent anti-inflammatory and antioxidant. It halts osteoarthritis progression, reduces inflammation, and protects the liver. Curcumin is vital in my medicine cabinet for managing inflammation and has contributed positively to my heart health.
Read More
9
Promotes heart health
1 people found this helpful
This product is excellent. I take curcumin twice daily with meals. It benefits the heart, reduces cholesterol, combats cancer cells, and provides anti-inflammatory effects.
Read More
8
Health maintenance
1 people found this helpful
I regularly purchase curcumin for its numerous benefits, including anti-oxidation and anti-inflammation. It helps with heart disease, high blood pressure, diabetes, and cardiovascular issues. I bought it for elderly health care and will continue repurchasing.
Read More
Frequently Asked Questions
9
Reduces joint pain
1 people found this helpful
After experiencing painful shoulders and toe joints, I found this product greatly eased my inflammation and pain, positively impacting my heart health.
9
Supports immunity
Curcumin is an excellent supplement for immunity. I notice its effectiveness at the first signs of illness and appreciate its contribution to heart health.
9
Promotes heart health
1 people found this helpful
This product is excellent. I take curcumin twice daily with meals. It benefits the heart, reduces cholesterol, combats cancer cells, and provides anti-inflammatory effects.
9
Eliminated pain relief
14 people found this helpful
This is a fantastic product. I use it for its anti-inflammatory properties, which have allowed me to nearly stop using Ibuprofen. My cardiologist considers me his most boring patient after having two heart stents for almost six years. I also take nattokinase and serrapeptase to maintain excellent cardiovascular health.
8
Health maintenance
1 people found this helpful
I regularly purchase curcumin for its numerous benefits, including anti-oxidation and anti-inflammation. It helps with heart disease, high blood pressure, diabetes, and cardiovascular issues. I bought it for elderly health care and will continue repurchasing.
8
Curcumin shows promise for metabolic health
We examined how curcumin, a key ingredient in turmeric, impacts cardiometabolic health in women with polycystic ovary syndrome (PCOS), a condition often linked to heart disease risks. In our systematic review, we analyzed data from eight randomized clinical trials to understand if curcumin could be beneficial for controlling various metabolic factors.
Our findings suggest that curcumin supplementation can lead to significant reductions in fasting blood sugar levels, insulin resistance, and total cholesterol among women suffering from PCOS. Specifically, we noticed substantial improvements in markers like the homeostasis model assessment of insulin resistance and the quantitative insulin sensitivity check index, which are crucial for heart health.
However, it’s important to highlight that while curcumin shows promise in addressing these metabolic issues, it did not significantly impact body mass index or other hormonal levels related to heart disease risk. Thus, while curcumin supplementation might improve certain metabolic factors, its direct effects on heart disease require further exploration.
Our findings suggest that curcumin supplementation can lead to significant reductions in fasting blood sugar levels, insulin resistance, and total cholesterol among women suffering from PCOS. Specifically, we noticed substantial improvements in markers like the homeostasis model assessment of insulin resistance and the quantitative insulin sensitivity check index, which are crucial for heart health.
However, it’s important to highlight that while curcumin shows promise in addressing these metabolic issues, it did not significantly impact body mass index or other hormonal levels related to heart disease risk. Thus, while curcumin supplementation might improve certain metabolic factors, its direct effects on heart disease require further exploration.
9
We aimed to explore how curcumin, a compound found in turmeric, can help reduce heart damage caused by ischemia-reperfusion injury (MIRI). This type of injury occurs when blood supply returns to the heart after a period of being blocked, and it can lead to complications such as cell death and heart dysfunction.
Through our study involving Sprague-Dawley rats and H9c2 heart cells, we observed that curcumin pretreatment significantly improved heart health. It reduced damage to the heart muscle, increased cell survival, and minimized instances of ferroptosis—a form of cell death that contributes to heart injuries.
We found that when MIRI occurred, certain proteins in heart cells that help regulate cell survival were adversely affected. These proteins, including Sirt1 and FoxO3a, normally help protect cells from stress but were inhibited during MIRI. Remarkably, curcumin activated these protective pathways again, promoting survival and reducing harmful processes like ferroptosis and apoptosis.
Our findings highlight curcumin's potential as a therapeutic agent against myocardial injury, as it helps maintain healthy heart function by influencing specific molecular pathways. We also addressed that blocking these pathways negated the benefits of curcumin, showcasing the importance of the Sirt1/AKT/FoxO3a signaling in its protective effect against heart disease.
Through our study involving Sprague-Dawley rats and H9c2 heart cells, we observed that curcumin pretreatment significantly improved heart health. It reduced damage to the heart muscle, increased cell survival, and minimized instances of ferroptosis—a form of cell death that contributes to heart injuries.
We found that when MIRI occurred, certain proteins in heart cells that help regulate cell survival were adversely affected. These proteins, including Sirt1 and FoxO3a, normally help protect cells from stress but were inhibited during MIRI. Remarkably, curcumin activated these protective pathways again, promoting survival and reducing harmful processes like ferroptosis and apoptosis.
Our findings highlight curcumin's potential as a therapeutic agent against myocardial injury, as it helps maintain healthy heart function by influencing specific molecular pathways. We also addressed that blocking these pathways negated the benefits of curcumin, showcasing the importance of the Sirt1/AKT/FoxO3a signaling in its protective effect against heart disease.
7
We conducted a randomized double-blind clinical trial involving 42 patients diagnosed with coronary slow flow phenomenon (CSFP). Participants were given either an 80 mg daily dose of highly bioavailable nano-curcumin or a placebo for 12 weeks. Our goal was to assess how this supplement could affect various heart-related factors, overall health quality, and symptoms of depression.
Interestingly, while we didn't observe significant changes in some inflammation markers, the results were promising in other areas. Patients who received nano-curcumin showcased improved control over their blood sugar levels compared to those on the placebo. Additionally, reports from standard health surveys indicated noteworthy enhancements in both physical and mental quality of life for the nano-curcumin group.
Furthermore, we saw a substantial reduction in depressive symptoms among the participants taking the curcumin supplement. This suggests that curcumin not only supports heart health by maintaining glycemic control, but also contributes positively to emotional well-being.
Overall, we can conclude that nano-curcumin might be a beneficial addition to managing CSFP and could help improve the quality of life and mental health for those grappling with this condition.
Interestingly, while we didn't observe significant changes in some inflammation markers, the results were promising in other areas. Patients who received nano-curcumin showcased improved control over their blood sugar levels compared to those on the placebo. Additionally, reports from standard health surveys indicated noteworthy enhancements in both physical and mental quality of life for the nano-curcumin group.
Furthermore, we saw a substantial reduction in depressive symptoms among the participants taking the curcumin supplement. This suggests that curcumin not only supports heart health by maintaining glycemic control, but also contributes positively to emotional well-being.
Overall, we can conclude that nano-curcumin might be a beneficial addition to managing CSFP and could help improve the quality of life and mental health for those grappling with this condition.
8
Curcumin shows promise for heart health
In our exploration of heart disease treatment, we focused on cardiac fibrosis, a condition that can lead to serious heart issues such as failure. We utilized a well-structured approach, employing both in-vitro and in-vivo techniques to assess the effectiveness of dendrosomal nano-curcumin (DNC), a powerful form of curcumin derived from turmeric.
To start, we induced cardiac fibrosis in primary cardiac fibroblasts using isoproterenol (ISO) and subsequently treated them with DNC. Through rigorous testing, we found that DNC significantly lessened the fibrotic effects of ISO, indicating its potential as a therapeutic agent.
Following this, we investigated the impact of ISO in a live mouse model and noticed that it triggered fibrosis not only in the heart but also in the lungs. The application of DNC before, during, or after ISO treatment led to a marked reduction in fibrosis symptoms. This suggests that DNC could serve as both a preventive agent and a treatment alternative for those facing heart challenges related to fibrosis.
Our findings also revealed interesting genetic insights indicating the COMP gene as a potential new marker associated with cardiac fibrosis. Overall, this research highlights the promising role of DNC in combating heart disease and offers a hopeful outlook for future treatments.
To start, we induced cardiac fibrosis in primary cardiac fibroblasts using isoproterenol (ISO) and subsequently treated them with DNC. Through rigorous testing, we found that DNC significantly lessened the fibrotic effects of ISO, indicating its potential as a therapeutic agent.
Following this, we investigated the impact of ISO in a live mouse model and noticed that it triggered fibrosis not only in the heart but also in the lungs. The application of DNC before, during, or after ISO treatment led to a marked reduction in fibrosis symptoms. This suggests that DNC could serve as both a preventive agent and a treatment alternative for those facing heart challenges related to fibrosis.
Our findings also revealed interesting genetic insights indicating the COMP gene as a potential new marker associated with cardiac fibrosis. Overall, this research highlights the promising role of DNC in combating heart disease and offers a hopeful outlook for future treatments.
9
We explored how turmeric, specifically its active component curcumin, can protect the heart in cases of ischemia/reperfusion injury. This phenomenon often occurs during acute myocardial infarction when the heart muscle suffers due to restricted blood flow followed by restoration. Our focus was to understand whether curcumin could mitigate the damage caused by this process.
Through our research, we observed that curcumin appeared to significantly improve cell viability and reduce factors indicating cell damage. We noted that, in settings of anoxia/reoxygenation injury, curcumin treatment successfully lowered oxidative stress markers and enhanced antioxidant defenses in the heart cells. This included positive impacts on important proteins involved in protecting cells from ferroptosis (a type of cell death) and apoptosis (programmed cell death).
Furthermore, curcumin also improved mitochondrial function, which is crucial for heart cell energy production and overall health. We found that curcumin pretreatment inhibited excessive autophagy activation, which otherwise could contribute to cell damage under stress. These protective effects were correlated with increased expression of HES1, a protein linked to cell survival.
However, we noticed that the protective effects of curcumin were diminished when we tested alongside ferroptosis inducers or autophagy activators. This indicates that while curcumin has robust protective capabilities against heart injury, its effectiveness can be influenced by other cellular processes in play.
In conclusion, curcumin shows promising potential as a natural treatment option to reduce heart damage from ischemia/reperfusion injury, primarily through its antioxidant properties and influence on critical survival pathways.
Through our research, we observed that curcumin appeared to significantly improve cell viability and reduce factors indicating cell damage. We noted that, in settings of anoxia/reoxygenation injury, curcumin treatment successfully lowered oxidative stress markers and enhanced antioxidant defenses in the heart cells. This included positive impacts on important proteins involved in protecting cells from ferroptosis (a type of cell death) and apoptosis (programmed cell death).
Furthermore, curcumin also improved mitochondrial function, which is crucial for heart cell energy production and overall health. We found that curcumin pretreatment inhibited excessive autophagy activation, which otherwise could contribute to cell damage under stress. These protective effects were correlated with increased expression of HES1, a protein linked to cell survival.
However, we noticed that the protective effects of curcumin were diminished when we tested alongside ferroptosis inducers or autophagy activators. This indicates that while curcumin has robust protective capabilities against heart injury, its effectiveness can be influenced by other cellular processes in play.
In conclusion, curcumin shows promising potential as a natural treatment option to reduce heart damage from ischemia/reperfusion injury, primarily through its antioxidant properties and influence on critical survival pathways.
References
- Mohammadi S, Ziaei S, Morvaridi M, Hasani M, Mirtaheri E, et al. Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose-Response Meta-Analysis. Health Sci Rep. 2025;8:e70525. doi:10.1002/hsr2.70525
- Zhao ST, Qiu ZC, Xu ZQ, Tao ED, Qiu RB, et al. Curcumin attenuates myocardial ischemia‑reperfusion‑induced autophagy‑dependent ferroptosis via Sirt1/AKT/FoxO3a signaling. Int J Mol Med. 2025;55. doi:10.3892/ijmm.2025.5492
- Beikzadeh B, Khani M, Zarinehzadeh Y, Abedini Bakhshmand E, Sadeghizadeh M, et al. Preventive and treatment efficiency of dendrosomal nano-curcumin against ISO-induced cardiac fibrosis in mouse model. PLoS One. 2024;19:e0311817. doi:10.1371/journal.pone.0311817
- Yuan Y, Huang H, Hu T, Zou C, Qiao Y, et al. Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1. Int J Mol Med. 2024;54. doi:10.3892/ijmm.2024.5434
- Abolfazli S, Butler AE, Kesharwani P, Sahebkar A. The beneficial impact of curcumin on cardiac lipotoxicity. J Pharm Pharmacol. 2024;76:1269. doi:10.1093/jpp/rgae102
- Soltani M, Hosseinzadeh-Attar MJ, Rezaei M, Alipoor E, Vasheghani-Farahani A, et al. Effect of nano-curcumin supplementation on cardiometabolic risk factors, physical and psychological quality of life, and depression in patients with coronary slow flow phenomenon: a randomized double-blind clinical trial. Trials. 2024;25:515. doi:10.1186/s13063-024-08354-9
- Luo X, Liu P, Ye X, He J, Lai Y, et al. Curcumin improves atrial fibrillation susceptibility by regulating tsRNA expression in aging mouse atrium. PeerJ. 2024;12:e17495. doi:10.7717/peerj.17495
- Tehrani SD, Hosseini A, Shahzamani M, Heidari Z, Askari G, et al. Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery. Clin Nutr ESPEN. 2024;62:57. doi:10.1016/j.clnesp.2024.05.003
- Mishra P, Sahoo DK, Mohanty C, Samanta L. Curcumin-loaded nanoparticles effectively prevent T-induced oxidative stress in rat heart. Cell Biochem Funct. 2024;42:e4070. doi:10.1002/cbf.4070
- Rezaei M, Soltani M, Alipoor E, Rezayat SM, Vasheghani-Farahani A, et al. Effect of nano-curcumin supplementation on angina status, and traditional and novel cardiovascular risk factors in overweight or obese patients with coronary slow flow phenomenon: a randomized double-blind placebo-controlled clinical trial. BMC Nutr. 2024;10:73. doi:10.1186/s40795-024-00877-3
- Cui J, Wang X, Dong L, Wang Q. Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous HS levels and further modulating mA. Mol Biol Rep. 2024;51:558. doi:10.1007/s11033-024-09478-6
- Hu Z. Exploring the mechanism of curcumin in the treatment of doxorubicin-induced cardiotoxicity based on network pharmacology and molecular docking technology. Medicine (Baltimore). 2024;103:e36593. doi:10.1097/MD.0000000000036593
- Yang C, Zhu Q, Chen Y, Ji K, Li S, et al. Review of the Protective Mechanism of Curcumin on Cardiovascular Disease. Drug Des Devel Ther. 2024;18:165. doi:10.2147/DDDT.S445555
- Mirfakhraie N, Shoorei H, Abedpour N, Javanmard MZ. Co-treatment with bone marrow-derived mesenchymal stem cells and curcumin improved angiogenesis in myocardium in a rat model of MI. Mol Biol Rep. 2024;51:261. doi:10.1007/s11033-023-09180-z
- Liang J, Chen J, Yang L, Wu D, Xiong L, et al. Curcumin alleviates atrazine-induced cardiotoxicity by inhibiting endoplasmic reticulum stress-mediated apoptosis in mice through ATF6/Chop/Bcl-2 signaling pathway. Biomed Pharmacother. 2024;171:116205. doi:10.1016/j.biopha.2024.116205
- Hamdy S, Elshopakey GE, Risha EF, Rezk S, Ateya AI, et al. Curcumin mitigates gentamicin induced-renal and cardiac toxicity via modulation of Keap1/Nrf2, NF-κB/iNOS and Bcl-2/BAX pathways. Food Chem Toxicol. 2024;183:114323. doi:10.1016/j.fct.2023.114323
